Medique® Pain-Off®

Compare active ingredient to Excedrin®



Medique® brand OTC's are the only brand available that reward you for purchasing. Learn more about our MediBucks Rebate Program here.

Medi-First® Brand


Product Information

For extra strength relief from the pain of headache, toothache, muscle aches and arthritis

  • Unit dose, tamper-evident packets
  • Spanish labeling where possible

Each tablet contains:
Acetaminophen 250mg
Aspirin 250mg
Caffeine 65mg


Available in the following package sizes:
*500 (250 x 2's) - Item 22813
200 (100 x 2's) - Item 22847
100 (50 x 2's) - Item 22833
24 (12 x 2's) - Item 22864 for commissaries
*MediBucks Point Value = 20



Drug Facts Information


Active ingredient (in each tablet): Acetaminophen 250 mg
Purpose: Pain reliever/fever reducer

Active ingredient (in each tablet): Aspirin (NSAID*) 250 mg
Purpose: Pain reliever/fever reducer
*nonsteroidal anti-inflammatory drug

Active ingredient (in each tablet): Caffeine 65 mg
Purpose: Pain reliever aid

Inactive ingredients
hypromellose, maltodextrin, microcrystalline cellulose, polyethylene glycol, povidone, sodium starch glycolate, starch, stearic acid, titanium dioxide


For the temporary relief of minor aches and pains associated with
muscular aches
minor arthritis pain
back pain
common cold
menstrual cramps
Temporarily reduces fever.


Reye's syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye's syndrome, a rare but serious illness.

Allergy alert: Aspirin (NSAIDs) may cause a severe allergic reaction which may include:
facial swelling
asthma (wheezing)

Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include:
skin reddening

If a skin or allergic reaction occurs, stop use and seek medical help right away.

Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take:
more than 4,000 mg of acetaminophen in 24 hours
with other drugs containing acetaminophen
3 or more alcoholic drinks every day while using this product

Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you:
are age 60 or older
have had stomach ulcers or bleeding problems
take a blood thinning (anticoagulant) or steroid drug
take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)
have 3 or more alcoholic drinks every day while using this product
take more or for a longer time than directed

Caffeine Warning: The recommended dose of this product contains about as much caffeine as a cup of coffee. Limit the use of caffeine-containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and, occasionally, rapid heart beat.

Do not use
with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
for more than 10 days for pain unless directed by a doctor
for more than 3 days for fever unless directed by a doctor
if you ever have had an allergic reaction to any other pain relievers/ fever reducers
right before or after heart surgery
if you are taking prescription drugs for gout, diabetes, or arthritis

Ask a doctor before use if
stomach bleeding warning applies to you
you have high blood pressure, heart disease, liver cirrhosis, or kidney disease
you are taking a diuretic
you have a history of stomach problems such as heartburn
you have asthma

Ask a doctor or pharmacist before use if you are
taking the blood thinning drug warfarin
under a doctor’s care for any serious condition
taking any other drug

When using this product
take with food or milk if stomach upset occurs

Stop use and ask a doctor if
you experience any of the following signs of stomach bleeding:
       feel faint
      vomit blood
      have bloody or black stools
       have stomach pain that does not get better
symptoms do not improve
pain gets worse or lasts more than 10 days
fever gets worse or lasts more than 3 days
ringing in the ears or loss of hearing occurs
redness or swelling is present in the painful area
any new symptoms appear

If pregnant or breast-feeding, ask a health care professional before use. It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. Prompt medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.


■ do not take more than directed

Adults and children: (12 years and older) Take 2 tablets with water every 6 hours as needed. Do not take more than 8 tablets in 24 hours.

Children under 12 years: Do not give to children under 12 years of age.

Other Information

read all product information before using
store at room temperature 59º-86ºF (15º-30ºC)
avoid excessive heat and humidity
tamper-evident sealed packets
do not use any opened or torn packets


Questions? Please contact us at 1-800-634-7680

Medique Products takes great care to ensure that the product you take is completely safe. This website contains current product information as of 7/31/20 and may differ from the information on the product packaging you may have.


Excedrin® is a registered trademark of Novartis Consumer Products.